Start by marinating your bite-sized chicken pieces in Italian dressing. Allow them to sit for at least 30 minutes to absorb the flavors.
In a large pot, bring water to a boil. Add the penne pasta and cook according to package instructions until al dente. Drain and set aside.
In a large skillet over medium heat, melt the butter. Add the marinated chicken, smoked sausage, sliced green bell pepper, and white onion. Sauté until the chicken is cooked through and the vegetables are tender, about 5-7 minutes.
Sprinkle the flour over the mixture in the skillet and stir to combine. Gradually pour in the heavy cream while whisking continuously to avoid lumps. Allow the sauce to simmer for a few minutes until it thickens.
Stir in the shredded parmesan cheese, shredded mozzarella, salsa, and Tony Chachere's Creole Seasoning. Mix well until the cheeses melt and the sauce is creamy.
Add the cooked penne pasta to the skillet and toss everything together, ensuring the pasta is well-coated with the creamy sauce. Cook for an additional 2-3 minutes to heat through.
Dish out the Cheddars New Orleans Pasta into serving bowls and garnish with additional parmesan cheese if desired. Enjoy the burst of flavors with each bite!