Preheat your oven to 350°F (175°C).
In a large mixing bowl, combine the softened cream cheese, sour cream, garlic powder, shredded cheddar cheese, and diced jalapenos. Mix until well combined and creamy.
Fold in the shredded Parmesan cheese into the mixture.
In a separate bowl, melt the salted butter and then add the Panko bread crumbs. Stir until the crumbs are coated in butter.
Spread the creamy jalapeno mixture evenly into your prepared baking dish. Sprinkle the buttery Panko topping over the dip, followed by an extra layer of shredded Parmesan cheese.
Place the baking dish in the preheated oven and bake for about 20-25 minutes, or until the top is golden and bubbly.
Once baked, let it cool slightly before garnishing with minced fresh parsley. Serve warm with tortilla chips, crackers, or sliced vegetables.