Preheat the oven to 350°F (175°C) and grease two 9-inch round cake pans.
In a bowl, whisk together flour, baking powder, baking soda, and salt.
In a separate bowl, cream the butter and sugar until light and fluffy, then add the eggs one at a time.
Mix in lime juice and zest, then alternate adding flour mixture and buttermilk to the wet ingredients.
Divide the batter evenly between the prepared pans and smooth the tops.
Bake for 25-30 minutes or until a toothpick inserted comes out clean.
Allow the cakes to cool in the pans for 10 minutes before transferring to a wire rack.
Frost with cream cheese frosting or lime glaze once completely cooled.