Start by bringing a large pot of salted water to a boil. Add the elbow macaroni noodles and cook until they are al dente. Drain and set aside.
In a large skillet, melt the butter over medium heat. Add the minced garlic and sauté for about 1 minute until fragrant. Sprinkle in the flour, whisking constantly for about 2 minutes until bubbly and slightly golden.
Gradually whisk in the half-and-half and heavy whipping cream, ensuring there are no lumps. Continue to whisk until the mixture thickens, about 4-5 minutes.
Reduce the heat to low and stir in the shredded cheddar cheese blend, mild cheddar cheese, white cheddar cheese, and mozzarella cheese. Mix until all the cheese has melted and the sauce is creamy and smooth.
Add the garlic powder, onion powder, paprika, salt, and black pepper to the cheese sauce. Stir well to combine.
Add the cooked elbow macaroni to the cheese sauce, stirring gently to coat the pasta evenly.
Serve the TikTok Mac and Cheese immediately, garnished with chopped fresh parsley, or bake by transferring to a baking dish and baking at 350°F (175°C) for 20-25 minutes until bubbly and golden.